Overview of Picked Chemical Compounds and Intermediates
Overview of Picked Chemical Compounds and Intermediates
Blog Article
one. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This is often an impurity related to bortezomib, a proteasome inhibitor used in the treatment method of numerous myeloma. Its synthesis or review is very important for ensuring the purity and protection of the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-seven): A precursor within the synthesis of abiraterone acetate, a drug used in the therapy of prostate most cancers by inhibiting androgen manufacturing.
Imatinib Intermediate (CAS NO. 152460-10-1): A key compound in the synthesis of imatinib, a drug that targets specific different types of most cancers, together with Long-term myelogenous leukemia (CML).
Docetaxel Intermediate: A compound Utilized in the synthesis of docetaxel, a chemotherapy medication that treats a variety of cancers for example breast, lung, and prostate most cancers.
2. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, 8): These are definitely intermediates in the synthesis of gemcitabine, an anti-cancer drug. Their study is essential for optimizing the manufacturing approach and ensuring high purity.
Lapatinib Intermediate (CAS NO. 231278-eighty four-five): Lapatinib is utilised to treat breast most cancers, and these intermediates are involved with its production.
Fulvestrant Intermediates: Fulvestrant is really an estrogen receptor antagonist Utilized in the procedure of breast cancer. Different intermediates assist in the synthesis of this drug.
Paclitaxel Aspect Chain Acid (CAS NO. 949023-sixteen-nine): This intermediate is Employed in the synthesis of paclitaxel, a chemotherapy drug efficient in dealing with cancers for instance ovarian, breast, and lung most cancers.
three. Other Noteworthy Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-three): A 6-tetraacetate chemotherapy drug Employed in the treatment of colorectal cancer and modest mobile lung most cancers.
3-Amino-one-hydroxyadamantane (CAS 702-82-9): This compound is involved in the synthesis of adamantane derivatives, which have different apps, together with antiviral Attributes.
Vildagliptin Intermediates: Used in the production of vildagliptin, an oral drug for kind 2 diabetes that inhibits the enzyme DPP-four to control blood sugar concentrations.
four. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 61259-forty eight-one): This compound is involved with the synthesis of varied gluconic acid derivatives, which happen to be used in meals, pharmaceutical, and industrial applications.
Canagliflozin Intermediate two: A precursor in the synthesis of canagliflozin, a CIS-3-HYDROXY-4-PHENYL-2-AZETIDINONE medication used to deal with style two diabetes by inhibiting sodium-glucose co-transporter 2 (SGLT2).